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Vertebral augmentation in spine surgery. J Am Acad Orthop Surg

209 MansourA.KhachaturianH.LewisM

In differentiated cells, high levels of DNA methylation occurred in the CpG-rich promoters of pluripotency-related genes ( Histone acetylation/deacetylation is mediated by histone acetyltransferases and HDACs, respectively

However, published human data remain sparse, and there are currently no large randomized clinical trials demonstrating safety and effectiveness for any approved indication